Alzheimer's research has made significant progress and advancements in the past decade, led by a greater investment in Alzheimer's-related studies. In 2024, research determined one particular biomarker in blood tests strongly correlated with the disease. Now, researchers say they have perfected a new blood test that goes beyond confirming the disease – it can detect the progression and the best ways to treat it.
The new research published by Nature Medicine on March 31, 2025 corresponds to a protein called tau that builds up in the brains of people with Alzheimer's. The blood test centers around a tau protein, MTBR-tau243, and those with the disease had higher levels of it in their blood. They found a strong association between MTBR-tau243 levels and how well people performed on memory tests. It's believed that the tau plays a role in damaging neurons, leading to memory loss.
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While tau has long been recognized as an early indicator of Alzheimer's, the ability to better detect it through a blood test, combined with the correlation to memory loss, represent a major advancement.
The breakthrough could allow for earlier interventions and more personalized treatment. For example, certain drugs may be able to help clear the brain of plaque buildup or tau tangles that contribute to the disease.
The findings complement another fresh study, which looks at spinal fluid to predict brain changes associated with Alzheimer's. That study also found a correlation with memory impairment, as NPR outlines, another step forward in understanding the disease and its progression.
Through the 2020s, more than 100 potential Alzheimer's treatments have entered clinical trials. There are some key risk factors that put you at a greater risk, but many other considerations. The new research underscores the importance of individualized care as science continues to progress on the complexities of this disease.
Key takeaways
- A new blood test can detect the progression of Alzheimer's and the best ways to treat it.
- Those with Alzheimer's had higher levels of MTBR-tau243 in their blood.
- There is a strong association between MTBR-tau243 levels and memory test performance.
- The breakthrough could allow for earlier interventions and more personalized treatment.
Daily living tips for those diagnosed with Alzheimer's
The Alzheimer's Association advocates these tips:
- Create a coping strategy - determine what tasks are necessary and find a solution that works best for you
- Set realistic goals and focus on what you can do today
- Accept help from others
- Seek support from others with Alzheimer's
Know someone who lives with Alzheimer's? Check out this guide.
