Amy Schumer is getting "real." The comedian and actress, who has long faced unfair scrutiny over her physical appearance and become an advocate of body positivity, is candidly opening up about her experience with GLP-1 drugs, again.
In a video shared on her Instagram, the comedian told fans that her intent is to always "keep it a hundred." Before diving in, Schumer reminded followers that she initially tried losing weight with Wegovy back in 2022, but had to stop because the side effects got to an excruciating level that she "couldn’t handle."
"I was one of those people that felt so sick and couldn’t play with my son. I was so skinny and he’s throwing a ball at me and [I couldn’t]," she previously said of her experience on Watch What Happens Live with Andy Cohen.
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But all that changed following a telehealth appointment with Midi Health, which Schumer is now an investor in. For her perimenopause symptoms, Schumer was prescribed two hormones: estrogen and progesterone. According to the Cleveland Clinic, hormone therapy can help alleviate uncomfortable side effects, including low libido, hot flashes, and weight gain.
She also began taking Mounjaro, a GLP-1 medication that is approved by the U.S. Food & Drug Administration (FDA) for weight loss. The main difference between Mounjaro and Wegovy is their active ingredients: Mounjaro contains tirzepatide, whereas Wegovy (and Ozempic) contain semaglutide.
The switch in weight-loss drugs, alongside her perimenopause treatment, has been "a really good experience," said Schumer, adding that she’s happy with the results thus far.
"My symptoms of being in perimenopause have disappeared. My hair is fuller, my skin is better, I have more energy. I want to 'get down' more, if you know what I mean," the Trainwreck star said in the video.
More specifically, she said, "Mounjaro’s been great." It’s worth noting that the weight-loss drug isn’t covered by insurance unless it’s being prescribed to treat diabetes or obesity, "which most of the Internet thinks I have," Schumer joked of the latter.
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This isn’t the first time fans have made inappropriate comments about Schumer’s appearance. After speculation about her "puffier than normal" face reached a boiling point in 2024, the Life & Beth star responded to haters in a snarky Instagram post.
"Thank you so much for everyone’s input about my face! I’ve enjoyed feedback and deliberation about my appearance as all women do for almost 20 years. And you’re right it is puffier than normal right now," she wrote.
Elsewhere in the caption, Schumer explained that "there are some medical and hormonal things going on in my world right now but I’m okay," citing her ongoing struggles with endometriosis.
In all seriousness, the comedian said of Mounjaro, "I'm having a really good experience, so I wanted to keep it real with you about that."
And while fans might notice changes in her physical appearance, Schumer said one area she’ll never touch is her lips. "I want to commit to you that I will never get lip fillers, so you can always enjoy that I have no top lip," she joked.
