This Is When You Should Take Tylenol Instead of Advil, Doctors Say

Experts say the two OTC pain medications are not always interchangeable.

When we need to treat our various aches and pains, most of us just reach for whichever painkiller we have nearby at the time—and that's often Advil or Tylenol, two of the most popular over-the-counter (OTC) options. But are these medications really interchangeable? According to experts, not exactly. There are some key differences between Advil (a brand name for ibuprofen) and Tylenol (a brand name for acetaminophen), so there are times when you might want to take one over the other. Read on to find out when experts say Tylenol is the right choice over Advil, and for more guidance on your meds, If You're Taking This Medication, the FDA Has a New Warning for You.

Take Tylenol instead of Advil when you have stomach pain.

Man Touching Aching Stomach Lying On Couch At Home

Seamus Flynn, a pharmacist and optometrist, says that Advil tends to have more side effects that can be "quite harsh on the stomach." These side effects include upset stomach, nausea, vomiting, and heartburn, according to WebMD. Leann Poston, MD, a licensed physician and health advisor for Invigor Medical, says that chronic use of ibuprofen medications can actually damage the lining of the stomach, which produces more stomach issues like "stomach ulcers, pain, and bleeding." Even the manufacturers of Advil suggest talking to your doctor before using Advil if you have a "history of stomach problems." And for more warnings, If You're Swallowing Your Medication With This, Stop Immediately.

Take Tylenol instead of Advil if you have a fever.

Sick woman lying in the bed covered with blanket with high temperature.

Both Advil and Tylenol work to reduce a fever, but you may want to still choose Tylenol when dealing with this symptom. Advil is a non-steroidal anti-inflammatory drug (NSAID), which directly targets pain caused by inflammation. So when you're dealing with a non-inflammatory issue, like reducing a fever, "Tylenol is probably your better choice," Poston says. And for medications to hold back on, If You're Taking This OTC Medicine More Than Twice a Week, See a Doctor.

Take Tylenol instead of Advil if you have kidney issues.

doctor examination x-ray film from mri roentgen at hospital.

If you have kidney problems, you should be reaching for Tylenol. According to Flynn, "Advil should not be used for people with kidney disease, as it can reduce the amount of blood flowing to the kidneys." And long-term use of this type of medication can also negatively affect your kidneys. Per Flynn, long-term use of Advil "can cause a chronic kidney disease called chronic interstitial nephritis." And for more up-to-date information, sign up for our daily newsletter.

But take Advil instead of Tylenol if you have liver issues.

Terrible stomachache. Frustrated handsome young man hugging his belly and keeping eyes closed. Disturbed male having pain in stomach

Mehmet Oz, MD, a cardiothoracic survey specialist and host of The Dr. Oz Show, says that Tylenol is broken down by the liver, while Advil is mostly broken down by the kidneys. Unfortunately, this means Tylenol can negatively affect your liver, especially if you're already experiencing liver issues or are predisposed to liver problems. "Taking too much [Tylenol] may cause you to have liver damage, which can manifest as yellowing of the skin or whites of your eyes," Oz explains. "You should be careful about taking Tylenol if you have issues with your liver, or if you drink a lot of alcohol, because alcohol is processed by the liver." And if you're worried about your liver, Drinking This Much Coffee Every Day Can Save Your Liver, Study Says.

And take Advil instead of Tylenol if you're dealing with any pain associated with inflammation.

Distressed woman sitting in a dentist's chair, holding her cheek and enduring a terrible toothache

If your pain is due to inflammation, then Advil is "the better choice" because it is a NSAID, Poston explains. Jessica Nouhavandi, PharmD, lead pharmacist and founder of online pharmacy Honeybee Health, says that Tylenol doesn't help with inflammation pain because "it does not have that anti-inflammatory effect."

"Advil blocks the production of chemicals in the body that contribute to pain and inflammation—so whenever there is redness, swelling, heat, or pain at a site," says Oz. "This makes it ideal for most back and neck pain, toothache, muscle sprains and strains, and menstrual cramps." And for more health advice, If You Drink This, You Could Become Resistant to Antibiotics, Study Says.

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