13 Warning Signs Your Pancreas Is Trying to Tell You Something's Wrong

Pancreatic cancer can be hard to identify—make sure you know these signs before it's too late.

Pancreatic cancer is a tricky cancer to identify. In the early stages, there might not be much—if any—indication something is even wrong, and that's exactly why doctors often refer to it as a "silent killer." Of the 57,600 cases that the American Cancer Society (ACS) estimates will be diagnosed in 2020, many won't be discovered until the cancer is at an advanced stage or has spread to other organs, as most signs and symptoms show up later on. That's why it's so important to know everything to be on the lookout for in order to catch pancreatic cancer as early as possible. Here are 13 pancreatic cancer warning signs you need to know. And to learn more about one famous figure's ongoing battle with the disease, check out 4 Symptoms of Pancreatic Cancer Alex Trebek Wished He'd Known Sooner.

Persistent abdominal pain

Man with stomach ache

Because the pancreas is located in your abdomen behind your stomach, a common symptom of pancreatic cancer is experiencing a dull pain in the stomach due to it pressing on the organ. According to Pancreatic Cancer UK, it's something that occurs in around 70 percent of pancreatic cancer cases. It might start off as just a little discomfort—something you brush off. But it can become more painful and persistent, signaling something is definitely wrong. And for health hints another organ is trying to give you, check out 25 Warning Signs Your Kidneys Send You.

Itchy skin

itchy palms

Itchy skin has many causes, and pancreatic cancer is one of them. The ACS says the itchiness occurs when bilirubin builds up in the skin, and you may notice it alongside the yellowing of your skin due to jaundice. If that's the case, slathering on lotion isn't going to help. Instead, it's important to book an appointment with a doctor as soon as you can.

Sudden-onset depression

older asian woman comforting older asian man on couch

Not many people realize pancreatic cancer can be responsible for depression, even before you realize you have it. Harvey B. Simon, MD, an internal medicine doctor in Boston, MA, told Harvard Health it's something those with pancreatic cancer may develop as the cancer grows. A 2018 study published in the journal Pancreas also backed that up, stating there's a pancreatic cancer-depression relationship—"particularly sudden-onset depression and anxiety in people who have never experienced this condition before." Being aware of this connection could help you get diagnosed and treated earlier. And for things you are doing that are damaging your mental well-being, check out 26 Things You're Doing That Are Hurting Your Mental Health.

Back pain

Woman rubbing aching back

Stomach pain isn't the only type of discomfort that goes hand-in-hand with pancreatic cancer. According to the ACS, back pain is common, too, and occurs when it spreads to the nerves surrounding the pancreas. While both stomach and back pain have many different possible causes, it's never a bad idea to check in with your doctor—especially when it's occurring often.

Unexplained weight loss

middle aged white man checks weight on scale

According to the Mayo Clinic, there are a few different reasons why weight loss can signal pancreatic cancer. As the cancer progresses, it consumes the body's energy, making you lose weight. And if the tumor is pressing on your stomach, it might make you feel full or make it hard for you to eat. Also, when your pancreas isn't functioning properly, it's not making enough of the digestive juices required to help your body process nutrients in the first place.

Gastrointestinal issues


If you start to experience light-colored, oily, or watery stools—and/or stools that are incredibly foul-smelling—when your bathroom habits are generally fine, pancreatic cancer is something to be aware of. According to Maryland Oncology Hematology, the issue occurs when the bile duct is blocked, which prevents bilirubin from getting to your stools and makes it hard for your body to digest fats properly.


middle aged white woman sweating and checking her pulse

If your once-strong self starts to feel very weak out of nowhere, your body might be trying to tell you something isn't right. The Moffitt Cancer Center says a common symptom of pancreatic cancer is experiencing extreme weakness in the limbs—something that doesn't just happen with this type of cancer, but many different types. That's because cancer essentially steals the nutrients your body needs in order for it to grow and cause harm.

Unexplained fatigue

A tired man adjusts his face mask while outdoors during the COVID-19 crises.

Like feeling weak, pancreatic cancer—and all cancers, for that matter—can also make you feel extremely fatigued. If there's no other explanation for why you're so tired, it's something to get checked out. A 2018 study published in the journal Acta BioMedica notes cancer-related fatigue is defined as feeling physically exhausted due to cancer or cancer treatments, and it can greatly impact your typical daily activities. And for more potential causes of your fatigue, check out 23 Reasons You're Tired All the Time.

Yellowing of the skin and eyes

asian doctor examining woman's eye with flashlight

Noticing your skin and eyes turning yellow is something you should never ignore. Jaundice can be due to conditions like liver disease and hepatitis, but Matthew Walsh, MD, a surgeon in Cleveland, OH, said on a podcast that it can also go hand-in-hand with pancreatic cancer. "You can have a relatively small tumor in the very end of the pancreas that can cause jaundice," he said. "[It's] one of the symptoms and that can occur relatively early." And for more vision-related issues, check out 17 Warning Signs Your Eyes Are Trying to Tell You About Your Health.

Sudden-onset diabetes

Man having his blood glucose levels checked by his doctor for diabetes

According to Walsh, developing diabetes suddenly at an older age is never something to take lightly. "You should look at the pancreas, because that can be one of the hallmarks," he said on a podcast. But how does that even happen? Johns Hopkins University says pancreatic cancer can trigger a case of sudden onset diabetes, or late onset diabetes, through "destroying the cells that make insulin, causing blood sugar levels to rise." And for more helpful information, sign up for our daily newsletter.

Dark urine

Person opening the door to go to the bathroom

While most people assume jaundice only affects your eyes and skin, that build-up of bilirubin in the body can also result in dark urine as well. According to the ACS, it's actually sometimes the first sign of jaundice, even before you notice a change in your skin or eyes. The darkening of the urine occurs when the levels of bilirubin in the blood increase, which changes urine to a brown color.

Nausea or vomiting

Woman with nausea lying on the couch

When you have pancreatic cancer, something you may experience is nausea or vomiting. According to the ACS, this occurs when the cancer puts pressure on your stomach, making it difficult for your food to pass through. This can also make you feel really nauseous—so much so that it might even cause you to vomit.

Blood clots

doctor examining muscle of patient, health questions after 50

You don't want to mess around with blood clots. According to GI Associates and Endoscopy Center, deep vein thrombosis—when a blood clot occurs in a large vein—can sometimes be the first sign of pancreatic cancer, and it typically shows up as redness, swelling, and pain in whichever leg has the blood clot. Since a piece of the blood clot can make its way to your lungs, making it hard to breathe, it's something to get checked out immediately.

Filed Under