If 1 of These 3 Body Parts Starts Swelling Up After Your Vaccine, Call a Doctor

The Mayo Clinic warns patients to be vigilant for a reaction in these areas.

With the United States' COVID vaccine program rolling out at a quicker pace, an increasing number of us are getting our shots against the virus. According to the latest data from the Centers for Disease Control and Prevention (CDC), as of Mar. 28, more than 51 million people in the U.S. had been fully vaccinated against COVID and more than 93 million had received at least one dose of the vaccine. Of course, that also means more people are experiencing the side effects that are expected to come along with the shot. Most of these are mild and pass quickly, but experts are warning patients to be aware of rare—but potentially more serious—reactions, particularly swelling in three specific areas after their COVID vaccine. To learn what you should be on the lookout for, read on, and for more on the latest vaccine news, check out The Only Medication You Should Take Before Your COVID Vaccine, Experts Say.

If you experience swelling of your lips, eyes, or tongue, that could be an allergic reaction to the vaccine.

Man with swollen lip

While COVID vaccine side effects may make you feel a little below par, most can be dealt with by simply resting up, staying hydrated, and using mild over-the-counter pain relievers. However, in a very small number of cases, an allergic reaction to the vaccine may take place.

The Mayo Clinic's advice warns patients to be on alert for a "continuous shortness of breath or wheezing," "redness, swelling or itchiness in areas of the body other than the limb in which the vaccine was given," and particularly, "swelling of the lips, eyes or tongue." In severe cases, where treatment with epinephrine or hospitalization is required, this is known as anaphylaxis.

"You'll likely be monitored for 15 minutes after getting a COVID-19 vaccine to see if you have an immediate reaction," warns the CDC. And for more rare, but less alarming reactions to the vaccine, check out The Strange New COVID Vaccine Side Effect That's Confusing Even Doctors.

Talk to your doctor immediately if you experience this reaction.

A senior woman listens as a female doctor gives a diagnosis. The doctor and patient are both wearing protective face masks as the patient is visiting the doctor's office during the COVID-19 crisis.

If you experience this kind of severe allergic reaction, the CDC says that you should contact your doctor and not get a second shot of that vaccine. "If the reaction was after an mRNA COVID-19 vaccine (either Pfizer-BioNTech or Moderna), you should not get a second shot of either of these vaccines," the agency says.

"An immediate allergic reaction happens within 4 hours of getting vaccinated and may include symptoms such as hives, swelling, and wheezing (respiratory distress)," the CDC notes. "Your doctor may refer you to a specialist in allergies and immunology to provide more care or advice." And for more on the latest news about the vaccine, check out This One Side Effect Signals a "Very Robust" Vaccine Response, Doctor Says.

Swelling of your arm, however, is to be expected.

young woman, scratching arm, red rash, wearing white shirt
Orawan Pattarawimonchai / Shutterstock

Some people who've gotten vaccinated against COVID have developed a red, itchy, swollen, or painful rash at their injection site, the CDC says. The rash, which has been dubbed "COVID arm," can crop up more than a week after you get vaccinated, the agency explains.

Most reports of "COVID arm" have been among those who got the Moderna vaccine, which is why some call it "Moderna arm." Esther Freeman, MD, a director at Massachusetts General Hospital in Boston, Massachusetts, recently told Dermatology Times, "What's been surprising is that with Moderna, people are seeing skin reactions on the vaccinated arm appear not within hours or a day of injection, but instead 8 days later." She added that a handful of people who were given the Pfizer vaccine also developed this delayed rash.

The CDC does not consider "COVID arm" to be a severe allergic reaction, like the swelling of your lips, eyes, or tongue, however. So those with this reaction should still get their second shot. And for more on the future of COVID vaccines, check out Moderna CEO Says This Is How Often You'll Need a COVID Vaccine.

Reacting to the vaccine generally is not a problem in itself.

Lonely sad woman deep in thoughts sitting daydreaming or waiting for someone in the living room with a serious expression, she is pensive and suffering from insomnia sitting on couch (Lonely sad woman deep in thoughts sitting daydreaming or waiting fo

The CDC warns that most of us can expect a range of mild side effects in response to the COVID vaccine, as with most vaccines. These side effects are essentially your body responding to what it perceives to be an infection, fighting it off and learning to recognize it the next time you encounter it.

"You may have some side effects, which are normal signs that your body is building protection," the CDC explains. "These side effects may affect your ability to do daily activities, but they should go away in a few days. Some people have no side effects."

Among those who do react to the vaccine, the most commonly reported side effects are pain and redness at the injection site, with tiredness, headache, muscle pain, chills, fever, and nausea presenting as well. And for the side effect cropping up most in Pfizer patients, check out The One Side Effect That's Much More Common With Pfizer, Data Shows.

John Quinn
John Quinn is a London-based writer and editor who specializes in lifestyle topics. Read more
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