How to Cancer-Proof Your Prostate
It's one of those weird anatomical-arboreal coincidences: The human prostate is about the size and shape of a walnut. But what if it really were a walnut? For one thing, you'd never get prostate cancer. Which sounds great, until you realize that you could get "walnut curcutio" or "walnut-husk maggot" instead. Better to deal with the devil you know.
And what a devil it is. Last year, 221,000 men (one of them Robert De Niro) were diagnosed with prostate cancer; that's more than lung, colon, and brain cancers combined. And nearly 29,000 men died of it last year.
These are grim statistics, but there's reason to be optimistic. Make that eight reasons. What follows is the latest, hot out-of-the-lab research on how you can prevent, detect, and treat the disease. Putting this science into action (read: more sex, more wine) won't confer absolute immunity, but it wilt make your prostate one tough nut to crack.
As if masturbation didn't already provide enough of a payoff, a recent Australian study found that DIY sex may also help prevent prostate cancer. The study of 2,338 men showed that the guys who masturbated five or more times a week were 34 percent less likely to develop prostate cancer by age 70 than those who handled matters less often. "Seminal fluid contains substances that are carcinogenic," says Graham Giles, Ph.D., the lead study author. "Regular ejaculation may help flush them out."
And in case you're wondering, no, masturbating more than once a day won't offer more protection, and yes, straight-up sex works, too. But before you have unprotected nookie with your partner, be sure she's been tested for cytomegalovirus, a type of herpes recently found in cancerous prostate tissue.
Be happy you're going bald.
Turns out the hair-loss drug Propecia has one impressive side effect. In a National Cancer Institute (NCl) study of 18,882 men, researchers found that the men who took 5 milligrams (mg) of Propecia, a.k.a. finasteride daily for 7 years had a 25 percent lower risk of prostate cancer than those taking a placebo. Finasteride blocks production of dihydrotestosterone, a hormone that triggers hair loss and prostate growth.
"It's the first study to prove that prostate cancer is preventable," says Peter Greenwald, M.D., the NCI's director of cancer prevention — and one of those 18,882 men. "My prostate's normal," he adds.
One caution: Men on finasteride had a slightly greater chance of being diagnosed with a more aggressive form of the disease than did the placebo takers. More research on the drug is needed, but if you're concerned about prostate cancer, discuss these findings with your doctor.
Wine and dine.
There's a good reason Western European men have lower prostate-cancer rates than we do. And it has nothing to do with Speedo thongs. New research suggests that certain staples of the Mediterranean diet have prostate cancer-fighting properties. For starters, a recent study published in the Journal of the National Cancer Institute shows that men who eat more than 10 grams (g) of garlic or scallions (about three cloves of garlic or 2 tablespoons of scallions) daily have a 50 percent lower risk of prostate cancer than those who eat less than 2 g. (Give credit to organosulfur compounds, which are common to both vegetables.)
Then there's red wine; red grapes are flush with resveratrol, an antioxidant found in some plants that may help inhibit the growth of prostate cancer, according to a report from the M.D. Anderson Cancer Center at the University of Texas. A glass or two of red wine daily should suffice. "If you drink too much," says Catherine O'Brian, Ph.D., the lead study author, "you can neutralize the beneficial effects."
Lower the bar.
Here's a PSA (public service announcement) regarding your PSA (prostate-specific antigen): Using a score of 4.1 or greater as the alarm for prostate cancer could prove fatal. A recent study of 6,691 men, published in the New England Journal of Medicine (NEJM), showed that this traditional threshold for ordering a follow-up biopsy may be missing 82 percent of prostate-cancer diagnoses in men under 60. "The threshold of 4.1 that's being used has never been rigorously studied," says Karen M. Kuntz, Sc.D., one of the study's authors. And while critics say a lower threshold will lead to unnecessary biopsies, Rinaa Punglia, M.D., another of the study authors, believes that the broader standard could be worth it. "It's a trade-off," she admits. "But it could save lives." So how low should you go? Dr. Punglia recommends that when you have your PSA level checked (annually beginning at age 50 — or 45 if you have a family history or are African-American), you observe a threshold of 2.6, especially if you're under age 60. According to the NEJM study, following this guideline doubled the cancer-detection rate, from 18 to 36 percent.
Calculate your risk.
Let's say your pSA is 2.6. You still may not need a biopsy. Instead, ask your doctor to use a nomogram. This needle-free analysis turns a patient's age, his PSA density (PSA divided by the volume of the prostate), his digital-rectal-exam result, and his transrectal-ultrasound result into a score that helps determine whether a biopsy is really warranted. "We can say whether or not, for your prostate, that's a high PSA," says Mark Garzotto, M.D., director of urologic oncology at the Portland VA Medical Center. In a study of 1,200 men, Dr. Garzotto found that if a nomogram had been used in every case, it would have spared 24 percent of the men from unnecessary biopsies.
Hit the spice rack.
Researchers at the Center for Holistic Urology at Columbia-Presbyterian Medical Center in New York City recently found that a blend of herbs including ginger, oregano, rosemary, and green tea reduced prostate-cancer cell growth by 78 percent in the lab. Sold as Zyflamend, it's thought to inhibit the activity of COX-2, a protein linked to the progression of the disease.
"We're using it with promising results in some of our patients," says Aaron Katz, M.D,, the center director. Another herbal option is FBL 101. When researchers at the National Cancer Institute gave FBL 101 to mice with prostate cancer, they found that it decreased a tumor blood-vessel growth factor called VEGF to undetectable levels. Crimp the blood supply and cancer can't survive, says William Figg, Pharm.D., the principal investigator. "Men who want to delay the time before they begin traditional treatment should check this out," he says. Get your doctor's okay before starting on either one.
Use CAD (Computer-Assisted Doctor).
The radical prostatectomy recently became a lot less radical, thanks to a new robotic version of the procedure. With the da Vinci system, doctors use three-dimensional imaging to direct two nimble robotic hands through a few small slits in the patient's abdomen to remove the cancerous prostate. According to data from the Vattikuti Urology Institute at the Henry Ford Health System in Detroit, 90 percent fewer men became incontinent and 50 percent fewer became impotent with the Da Vinci system than with manual gland removal. "It's like playing golf with a titanium driver versus a wooden driver." says chief of urology Mani Menon, M.D. Another plus: Patients spent an average of 1.5 days in the hospital, compared with 2.3 days for open surgery.
Rehab your erections.
Unless you're Cristiano Ronaldo, this one's a no-brainer: Take a nerve graft from your ankle and save your sex life. The cavernous nerves, a.k.a. the boner bugle corps, are often a casualty of prostate removal if cancer has (or might) spread outside the gland. But by replacing the cavernous nerves with the sural nerve that runs along the ankle, as many as 9,000 men a year could recover erectile function, says Peter Scardino, M.D., one of the developers of the procedure and chairman of urology at Memorial Sloan-Kettering Cancer Center in New York City. "If you've got only one [cavernous] nerve left, you're firing on four cylinders, but if I do a graft, like you're firing on seven out of eight." And don't worry; a slight numbness in your foot is the effect. Talk to your urologist where to find a surgeon expert in sural-nerve grafting.